Oct 11, 2017

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    The long half-life (~30 hours) enables convenient once-daily dosing regimens.

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    Rare cases of hepatotoxicity, including fatal hepatic necrosis, have been reported.

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    Can be administered via nasogastric tube as the oral suspension is well-absorbed.

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    The "trailing effect" in vitro can make susceptibility interpretation for Candida challenging.

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    Liver enzyme elevation is the most common laboratory abnormality observed.

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    May unmask or exacerbate cutaneous lupus erythematosus.

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    Therapeutic drug monitoring is not routinely required but can be useful in specific scenarios.

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    Serves as a model for the development of other triazole antifungal agents.

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    The long half-life (~30 hours) enables convenient once-daily dosing regimens.

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    Diflucan is a critical component of induction-consolidation-maintenance strategies for cryptococcosis.

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